Marcelo Farina Selected Research

Probucol (Lorelco)

8/2020	Probucol Protects Neuronal Cells Against Peroxide-Induced Damage and Directly Activates Glutathione Peroxidase-1.
8/2020	New Probucol Analogues Inhibit Ferroptosis, Improve Mitochondrial Parameters, and Induce Glutathione Peroxidase in HT22 Cells.
1/2018	Antidepressant Effects of Probucol on Early-Symptomatic YAC128 Transgenic Mice for Huntington's Disease.
4/2013	Effects of lifestyle modifications on cognitive impairments in a mouse model of hypercholesterolemia.
3/2013	Probucol affords neuroprotection in a 6-OHDA mouse model of Parkinson's disease.
3/2013	Succinobucol versus probucol: higher efficiency of succinobucol in mitigating 3-NP-induced brain mitochondrial dysfunction and oxidative stress in vitro.
1/2013	Probucol increases striatal glutathione peroxidase activity and protects against 3-nitropropionic acid-induced pro-oxidative damage in rats.
12/2012	Does methylmercury-induced hypercholesterolemia play a causal role in its neurotoxicity and cardiovascular disease?
3/2012	Probucol modulates oxidative stress and excitotoxicity in Huntington's disease models in vitro.

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Marcelo Farina Research Topics

Disease

17	Mitochondrial Diseases (Mitochondrial Disease) 01/2022 - 12/2007
8	Body Weight (Weight, Body) 01/2021 - 11/2004
8	Poisoning 10/2020 - 12/2007
8	Parkinson Disease (Parkinson's Disease) 01/2020 - 01/2011
7	Neuroblastoma 08/2020 - 08/2009
6	Neurodegenerative Diseases (Neurodegenerative Disease) 11/2020 - 02/2013
6	Cognitive Dysfunction 01/2020 - 01/2012
5	Huntington Disease (Huntington's Disease) 09/2018 - 03/2012
5	Hypercholesterolemia 04/2014 - 01/2012
4	Memory Disorders (Memory Loss) 02/2016 - 02/2007
4	Alzheimer Disease (Alzheimer's Disease) 07/2015 - 04/2013
3	Hyperlipoproteinemia Type II (Familial Hypercholesterolemia) 01/2020 - 10/2013
3	Atherosclerosis 02/2017 - 11/2008
3	Neuroinflammatory Diseases 01/2017 - 01/2014
3	Glioma (Gliomas) 09/2013 - 09/2010
2	Dementia (Dementias) 11/2020 - 04/2014
2	Cardiovascular Diseases (Cardiovascular Disease) 02/2017 - 12/2012
2	Dyskinesias (Dyskinesia) 10/2016 - 01/2011
2	Gliosis 03/2016 - 01/2014
2	Neoplasms (Cancer) 12/2015 - 11/2004
2	Depressive Disorder (Melancholia) 12/2014 - 02/2013
2	Hypothyroidism 01/2013 - 09/2007
2	Amyloid Plaque 02/2012 - 02/2007
2	Pain (Aches) 12/2011 - 04/2009
2	Necrosis 04/2009 - 07/2008
2	Alcoholic Liver Diseases (Alcoholic Liver Disease) 05/2006 - 02/2006
2	Anemia 05/2005 - 11/2004
1	COVID-19 01/2022
1	Ischemic Stroke 08/2021
1	Autism Spectrum Disorder 11/2018
1	Ataxia (Dyssynergia) 10/2018
1	Inflammation (Inflammations) 03/2018
1	Disease Progression 01/2018

Drug/Important Bio-Agent (IBA)

13	AntioxidantsIBA 01/2019 - 02/2007
9	Probucol (Lorelco)FDA Link 08/2020 - 03/2012
7	CholesterolIBA 01/2020 - 12/2012
6	LDL Receptors (LDL Receptor)IBA 01/2020 - 01/2012
6	MercuryIBA 02/2017 - 01/2005
6	Glutamic Acid (Glutamate)FDA Link 01/2017 - 04/2004
5	Pharmaceutical PreparationsIBA 01/2022 - 12/2012
5	Cholinergic Agents (Cholinergics)IBA 10/2020 - 01/2008
5	EnzymesIBA 08/2020 - 09/2007
5	Sulfhydryl Compounds (Thiols)IBA 08/2017 - 01/2005
5	Peptides (Polypeptides)IBA 07/2015 - 02/2007
5	Amyloid (Amyloid Fibrils)IBA 07/2015 - 02/2012
5	AcetylcholinesteraseIBA 04/2014 - 01/2008
4	PeroxidesIBA 08/2020 - 12/2009
4	Glutathione (Reduced Glutathione)IBA 01/2019 - 02/2007
4	diphenyldiselenideIBA 01/2019 - 04/2009
4	Oxidopamine (6 Hydroxydopamine)IBA 05/2016 - 01/2010
4	Malathion (Karbofos)FDA LinkGeneric 03/2016 - 01/2008
4	LipidsIBA 03/2016 - 12/2012
4	LDL Lipoproteins (beta Lipoproteins)IBA 01/2016 - 11/2008
4	oxidized low density lipoproteinIBA 01/2016 - 11/2008
3	Oxidants (Oxidizing Agents)IBA 01/2019 - 12/2007
3	Proteins (Proteins, Gene)FDA Link 01/2018 - 04/2009
3	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 10/2017 - 01/2011
3	CalciumIBA 01/2017 - 11/2011
3	succinobucol (AGI 1067)IBA 01/2017 - 03/2013
3	Neuroprotective AgentsIBA 01/2015 - 01/2011
3	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 02/2013 - 01/2010
3	OximesIBA 12/2011 - 01/2008
3	Glutathione PeroxidaseIBA 08/2009 - 01/2008
2	MetalsIBA 01/2022 - 11/2020
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2022 - 09/2010
2	ManganeseIBA 11/2020 - 09/2015
2	Antidepressive Agents (Antidepressants)IBA 01/2018 - 12/2014
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 10/2016 - 11/2011
2	3-nitropropionic acidIBA 03/2016 - 03/2013
2	Succinate Dehydrogenase (Fumarate Reductase)IBA 03/2016 - 03/2013
2	GuanosineIBA 12/2014 - 04/2004
2	LDL CholesterolIBA 04/2014 - 12/2012
2	Organoselenium CompoundsIBA 08/2013 - 11/2004
2	Propylthiouracil FDA Link 01/2013 - 09/2007
2	Glucose (Dextrose)FDA LinkGeneric 01/2013 - 11/2009
2	pralidoxime (Protopam Chloride)FDA Link 12/2011 - 09/2010
2	SeleniumIBA 11/2010 - 05/2005
2	Therapeutic UsesIBA 09/2010 - 11/2004
2	Thiobarbituric Acid Reactive SubstancesIBA 04/2009 - 01/2005
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 04/2009 - 07/2008
2	Capsaicin (Zostrix)FDA Link 04/2009 - 07/2008
2	Interleukin-1beta (Interleukin 1 beta)IBA 04/2009 - 07/2008
2	SolutionsIBA 08/2007 - 04/2006
1	Phospholipid Hydroperoxide Glutathione PeroxidaseIBA 01/2022
1	Peptide Hydrolases (Proteases)FDA Link 01/2022
1	IronIBA 01/2022
1	Protease Inhibitors (Protease Inhibitor)IBA 01/2022
1	Tissue Plasminogen Activator (Alteplase)FDA Link 08/2021
1	LeptinIBA 01/2021
1	O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphateIBA 10/2020
1	Cholinesterase Inhibitors (Anticholinesterases)IBA 10/2020
1	ParaquatIBA 01/2020
1	ManebIBA 01/2020
1	PesticidesIBA 11/2018
1	Omega-3 Fatty Acids (Omega 3 Fatty Acids)IBA 10/2018
1	Brain-Derived Neurotrophic Factor (BDNF)IBA 09/2018
1	LipopolysaccharidesIBA 03/2018
1	polyglutamineIBA 01/2018
1	NeurotoxinsIBA 10/2017

Therapy/Procedure

3	Therapeutics 01/2022 - 11/2010